Mystic Conference

Mechanisms and Therapeutics in Immunotherapy

This course is designed to introduce basic concepts and the science of immunology with a state-of-the-art discussion of immune-based therapies in transplantation and cancer.

The University of Connecticut (UConn), a leader in immunology education for the pharmaceutical industry, educators and health care providers,  proudly presents a continuing professional development activity for  PhD’s, Medical Liaisons, Research Scientists and Clinical Pharmacists.

This was my 4th time taking immunology courses; I still felt it very useful to connect the dots and to update my knowledge.”    -spring 2015 conference

Refreshed what I learned about Immunology and provided me with new knowledge”   -spring 2015 conference

I loved Dr. Hubbard’s portion, it was the best overview to get ready for the other topics
-Mystic  Conference 2017

MysticJoin us at the beautiful…..
Mystic Marriott Hotel & Spa
625 North Road
Groton, CT  06340

June 25-26, 2018

 

Registration is OPEN!

Hotel Rooms can be reserved in our block at special pricing until June 4, 2018 at a rate of  $149/night using the following hotel link https://aws.passkey.com/go/UCONNPharmacy2018

Pricing

MC-Industry: $1200
MC-Academia/MD:$800
MC-Trainee/Resident/Fellow: $400
MC-Practicing PharmD/RPh:  $400
MC-Adult Guest Lobster: $57
MC-Adult Guest Chicken: $49
MC-Adult Guest Vegetarian: $49
MC-Child Guest: $20

Who should attend:

  • PhD’s, MD’s, PharmD’s, Medical Liaisons, and Research Scientists interested in advancing their knowledge and skills in the area of immunology mechanisms and therapeutics
  • Researchers in companies with an interest or focus in immunotherapeutics
  • Graduate students, fellows, or trainees interested in increasing their basic and expanded knowledge of current immunotherapy concepts

Full Program Brochure

Agenda – MIC 2018

Format: 

  • A UConn website (HuskyCT) has been developed for this course as a learning management tool for posting of handouts, supplemental readings, web links, etc. There is no formal text book.
  • Lectures will be provided in person at the Mystic Marriott Hotel by faculty from the University of Connecticut, Yale New Haven Hospital, Columbia University and Brigham and Women’s Hospital

Day 1   June 25, 2018

  • 7:30-8:15 m. – Registration and Continental Breakfast
  • 8:15-8:30 m. – Opening Remarks
    Jill Fitzgerald, PharmD -University of Connecticut School of Pharmacy, Storrs, CT

8:30 – 9:30           Introduction to the Immune System and Cell Signaling
Andrea K. Hubbard, Ph.D., Associate Professor UCONN School of Pharmacy

At the conclusion of this presentation, participants will be able to:

  1. Describe basic principles of the immune system
  2. Discuss signaling mechanisms underlying B cell responses to antigen
  3. Discuss signaling mechanisms underlying T cell responses to antigen
  4. Discuss signaling mechanisms underlying activation of toll like receptors

ACPE UAN:  0009-0000-17-025-L04-P (0.1 CEU or 1 contact hour) (Knowledge-based) 

9:30 – 9:45 a.m.                  Break

9:45 – 10:45       Innate Immunity/Inflammation; MHC and Antigen Processing
Andrea K. Hubbard, Ph.D. Associate Professor UCONN School of Pharmacy

At the conclusion of this presentation, participants will be able to:

  1. Discuss the role of immune cells, cell surface proteins and mediators in activation of the immune response
  2. Recognize the relationship between innate and adaptive immunity and immune surveillance
  3. Identify the functions of cell mediated immunity
  4. Identify the function of humoral immunity

ACPE UAN: 0009-0000-17-026-L04-P (0.1 CEU or 1 contact hour) (Knowledge-based) 

10:45 – 11:45      Antigen Receptor Diversity in Primary and Secondary Responses
Andrea K. Hubbard, Ph.D. Associate Professor UCONN School of Pharmacy

At the conclusion of this presentation, participants will be able to:

  1. Discuss the mechanisms underlying antigen receptor diversity in T cell responses
  2. Discuss the mechanisms underlying antigen receptor diversity in B cell responses
  3. Describe the mechanisms underlying clonal selection and primary/secondary immune responses
  4. Discuss the big picture to put it all together

ACPE Number:  0009-0000-18-042-L04-P  (0.1 CEU or 1 contact hour) (Knowledge-based)

11:45-12:30 p.m.               Lunch on site 

12:30 – 1:30        Immune Tolerance
Lawrence Silbart, MPH, Ph.D., Professor of Allied Health Sciences; UCONN

At the conclusion of this presentation, participants will be able to:

  1. Identify the role of central & peripheral tolerance in immune homeostasis
  2. Identify mechanisms underlying extrinsic mechanisms of acquired tolerance
  3. Recognize the role of tolerance in successful transplantation
  4. Recognize the role of tolerance in the tumor microenvironment
    ACPE Number: 0009-0000-18-033-L04-P (0.1 CEU or 1 contact hour) (Knowledge-based)

1:30 – 2:30           Immune Defense Against Pathogens
Lawrence Silbart, MPH, Ph.D., Professor of Allied Health Sciences; UCONN

At the conclusion of this presentation, participants will be able to:

  1. Recognize the importance of innate immune defense in protection
  2. Recognize the importance of adaptive immune defense in protection
  3. Describe the mechanisms of protection against select pathogens (polarization of T cell subpopulations)
  4. Describe evasion of immune defense by select pathogens

ACPE Number:  0009-0000-18-034-L04-P (0.1 CEU or 1 contact hour) (Knowledge-based)

2:30 – 2:45 a.m.                  Break                

2:45 – 3:45           Efficacy of Vaccines
Lawrence Silbart, MPH, Ph.D., Professor of Allied Health Sciences; UCONN

At the conclusion of this presentation, participants will be able to:

  1. Describe the types of vaccines and their mechanisms of action
  2. Describe the clinical implications of vaccines in disease prevention
  3. Identify safety and efficacy of vaccine types in the young and elderly
  4. Identify safety and efficacy of vaccine types in patients with altered immunocompetence

ACPE Number:  0009-0000-18-035-L06-P (0.1 CEU or 1 contact hour) (Knowledge-based) 

3:45-5:30 p.m.                   Time on your own

6:00 -9:00 p.m.                 Dinner at Abbotts Lobster in the Rough (BYOB)

 

Day 2   June 26, 2018 

8:15 – 9:00 a.m. – Continental Breakfast 

9:00 – 10:00        Tumor Immunotherapy: Tumor Vaccines
Trinh Pham, Pharm.D., BCOP,  Associate Clinical Professor UCONN School of Pharmacy

At the conclusion of this presentation, participants will be able to:

  1. Discuss basic principles of tumor biology and tumor immune surveillance
  2. Describe the mechanisms underlying cancer cell vaccines and oncolytic T-VEC therapy in select malignancies
  3. Describe the clinical application and relevancy of therapeutic cancer vaccines
  4. Discuss ongoing clinical trials of cancer cell vaccines as part of treatment modality for cancer

ACPE Number:  0009-0000-18-036-L06-P (0.1 CEU or 1 contact hour) (Knowledge-based) 

10:00 – 10:15 a.m.             Break 

10:15 – 11:15      Tumor Immunotherapy: Checkpoint Inhibitors
Sarah Weiss, MD; Assistant Professor of Medicine (Medical Oncology) Yale Cancer Center

At the conclusion of this presentation, participants will be able to:

  1. Describe the mechanisms underlying immune checkpoint inhibitors
  2. Describe the evolving role of predictive biomarkers
  3. Recognize the efficacy of this treatment in select cancers
  4. Recognize and understand management of immune-related adverse reactions of treatment
    ACPE Number: 0009-0000-18-037-L01-P (0.1 CEU or 1 contact hour) (Knowledge-based)

11:15 – 12:15       Tumor Immunotherapy: Chimeric Antigen Receptor (CAR) T cell therapy
Iris Isufi, MD; Assistant Professor of Medicine (Hematology); Yale University

At the conclusion of this presentation, participants will be able to:
1.  Describe the mechanisms underlying CAR T cell therapy
2.  Describe the efficacy of this treatment in lymphoid malignancies and select patient populations
3.  Explain CAR T cell therapy as part of other treatment modalities
4.  Recognize the management of adverse reactions from this therapy

ACPE Number:  0009-0000-18-038-L01-P (0.1 CEU or 1 contact hour) (Knowledge-based)   

12:15-1:00 p.m. Lunch on site

1:00 – 2:00           Transplantation Immunology: How to choose?
Elizabeth Cohen, Pharm.D., BCPS, Clinical Pharmacy Specialist, Yale New Haven Hospital

At the conclusion of this presentation, participants will be able to:

  1. Describe the mechanisms underlying rejection and tolerance of organ/bone marrow transplantation
  2. Describe the goals and mechanisms underlying induction and maintenance therapy in transplantation
  3. Recognize the needs of specific patient populations in transplantation
  4. Recognize the role of the transplant clinician in infection prophylaxis and successful graft transplantation

ACPE Number:  0009-0000-18-039-L01-P (0.1 CEU or 1 contact hour) (Knowledge-based)

2:00 – 3:00         Transplantation Immunology: Drug – drug Interactions
Demetra Tsapepas, Pharm.D., BCPS, FAST, Assistant Professor of Clinical Surgical Sciences,
Columbia University

At the conclusion of this presentation, participants will be able to:

  1. Describe the drug-drug interactions reported for induction/maintenance therapies
  2. Identify the role of cytochrome P450 enzymes and other mechanisms in these interactions
  3. Identify the impact of over-the-counter and complementary and alternative medications in these interactions
  4. Describe appropriate management of key drug-drug interactions

ACPE Number:  0009-0000-18-040-L01-P  (0.1 CEU or 1 contact hour) (knowledge-based)

3:00 – 3:15 p.m.                 Break                                                               

3:15 – 4:15           Transplantation Immunology: Newer Rejection Treatment Options
Steven Gabardi, Pharm.D.; Assistant Professor of Medicine; Brigham and Women’s Hospital

At the conclusion of this presentation, participants will be able to:  

  1. Recognize the efficacy and safety issues related to modern day immunosuppression.
  2. Describe the mechanisms underlying new transplant medications
  3. Compare and contrast newer transplant therapies with traditional ones
  4. Recognize barriers to development of new transplant therapies

ACPE Number:  0009-0000-18-041-L04-P (0.1 CEU or 1 contact hour) (Knowledge-based)